Gefitinib, 500 mg

STEMCELL Technologies supplies this laboratory chemical as a crystalline solid identified by the chemical name N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine (CAS No. 184475-35-2), also referenced by the synonyms Gefonib and ZD1839. According to the manufacturer, the compound is a tyrosine kinase inhibitor: Gefitinib (Iressa™) inhibits EGFR and prevents cancer cell growth.

Intended for laboratory research use only, it is not for human or animal diagnostic or therapeutic applications unless otherwise stated. The safety data sheet classifies it as acutely toxic if swallowed (Category 4, with a calculated oral ATEmix of 500.00 mg/kg) and warns that it is very toxic to aquatic life. Reported solubility values are approximately 0.5 mg/mL in a 1:1 DMSO:PBS mixture at pH 7.2, about 0.3 mg/mL in ethanol, and roughly 20 mg/mL in both DMF and DMSO.

The molecular formula is C22H24ClFN4O3 with a molecular weight of 446.9. The substance is stable under normal conditions but should be kept away from strong oxidizing agents; thermal decomposition can release carbon monoxide, carbon dioxide, hydrogen fluoride, nitrogen oxides, and hydrogen chloride gas.