GANT 58, 5 mg

STEMCELL Technologies supplies this small-molecule inhibitor of the Hedgehog signaling pathway, which acts downstream of Smoothened and Suppressor of Fused (SUFU) to block GLI1 nuclear accumulation. The compound has demonstrated antiproliferative and antitumor activity in published studies and is provided as a crystalline solid with a stated purity of ≥ 98%.

Also known by the synonym NSC 75503, the chemical name is 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis-pyridine (CAS 64048-12-0). The molecular formula is C₂₄H₁₆N₄S with a molecular weight of 392.5 g/mol. Reported solubility values are 2.5 mg/mL in DMF, 0.50 mg/mL in DMF:PBS (pH 7.2) at a 1:1 ratio, 1.1 mg/mL in DMSO, and 1.4 mg/mL in ethanol.

Published cancer research applications include reducing anchorage-independent growth in Ewing sarcoma cells, inhibiting prostate cancer tumor growth, and inducing cell cycle arrest and apoptosis in acute T cell leukemia cells. The product is stable at -20 °C when protected from prolonged light exposure, with a shelf life of 12 months from the date of receipt. For use as a cell culture supplement, stock solutions should be diluted into culture medium immediately before use, and final DMSO concentration should be kept below 0.1% due to potential cell toxicity.