(±)-Flurbiprofen, 1 g

A cell-permeable, non-steroidal anti-inflammatory compound supplied by STEMCELL Technologies as a crystalline solid. The substance, with the chemical name 2-(3-fluoro-4-phenylphenyl)propanoic acid and synonym Ansaid, has the molecular formula C15H13FO2 and a molecular weight of 244.3 g/mol (CAS 5104-49-4). It acts as a non-selective inhibitor of cyclooxygenase, with reported EC50 = 0.1 and 0.4 µM for recombinant human COX-1 and COX-2, respectively.

Supplied at a stated purity of ≥ 99%, the material is soluble at approximately 100 mg/mL in ethanol, DMF, and DMSO, with stock solutions in DMSO or absolute ethanol typically prepared at ≤ 400 mM. As supplied, the product is stable at room temperature (15 - 25°C) for 12 months from date of receipt; prolonged exposure to light should be avoided, and a desiccant is recommended for long-term storage. Because the compound has low solubility in aqueous media, stock solutions should be diluted into culture medium immediately before use, with final DMSO concentration kept below 0.1% due to potential cell toxicity.

Intended for laboratory chemical use only, the compound carries the GHS signal word "Danger" and hazard statements H301 (Toxic if swallowed) and H361 (Suspected of damaging fertility or the unborn child). Reported acute oral values include an LD50 of 117 mg/kg in rat and an oral TDLo of 14 mg/kg/7D (intermittent) in woman. The product is classified as Acute Toxicity: Oral, Category 3, and Reproductive Toxicity, Category 2. Published research applications include maintenance of self-renewal and pluripotency in human embryonic stem cells and inhibition of tumor growth in models of prostate cancer, familial adenomatous polyposis, and brain cancer. For transport, the material is shipped under UN 2811, Toxic solids, organic, n.o.s. (Flurbiprofen), as class 6.1 (POISON), packing group III.