FK-866, 10 mg

A potent and selective small-molecule inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD+ salvage biosynthesis pathway. By blocking NAMPT activity, FK-866 rapidly depletes intracellular NAD+ pools, making it a widely used tool compound for probing cellular energy metabolism, mitochondrial function, and the dependence of rapidly proliferating cells on nicotinamide recycling.

Applied across cancer biology studies to induce apoptosis in tumor cell lines, in investigations of glycolysis and oxidative phosphorylation, and in models of neurodegeneration and inflammation where NAD+ consumption is implicated, the inhibitor is typically reconstituted in DMSO for in vitro assays or formulated for in vivo administration, with cell culture and xenograft protocols commonly cited in peer-reviewed literature.

Supplied as 10 mg of lyophilized powder in a single vial from STEMCELL Technologies, the product should be stored at -20 °C, protected from light and moisture, to preserve activity across freeze-thaw cycles. Intended for research use only in laboratory settings exploring NAD+ metabolism and therapeutic targeting of NAMPT.