Erastin, 1 mg

Erastin from STEMCELL Technologies is a ferroptosis inducer supplied for laboratory research. The compound is identified by the synonym 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone (equivalently 2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one) and carries CAS No. 571203-78-6. Its molecular weight is 547.1 and molecular formula C30H31ClN4O4, with the substance described as a crystalline solid.

The manufacturer's Safety Data Sheet classifies the material under the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200). Under the current revision it is listed as Acute Toxicity – Oral Category 3 with the hazard statement "Toxic if swallowed." An earlier SDS revision additionally listed Acute Toxicity – Dermal Category 3 and Acute Toxicity – Inhalation (Dusts/Mists) Category 3, with statements "Toxic in contact with skin" and "Toxic if inhaled." The calculated ATEmix (oral) is 100.00 mg/kg. The substance carries UN/ID no. 2811. The SDS reports solubility in DMF at 10 mg/mL, in DMSO at 5 mg/mL, and in DMSO:PBS (pH 7.2) at a 1:2 ratio of 0.25 mg/mL. Storage is described in the accompanying Product Information Sheet, and the product is handled in accordance with good industrial hygiene and safety practice.