Doxorubicin (Hydrochloride), 25 mg

From STEMCELL Technologies, this laboratory chemical is an anthracycline antibiotic that intercalates DNA and inhibits DNA topoisomerase II.

Supplied as a crystalline solid, it has a molecular weight of 580.0 and a molecular formula of C27H29NO11 • HCl (CAS 25316-40-9), and is also known by the synonym DOX. It is intended for laboratory use and is listed in the Stem Cell Identification & Isolation product category.

The safety data sheet classifies the substance as Acute toxicity – Oral Category 4 and Carcinogenicity Category 1B, with hazard statements "harmful if swallowed" and "may cause cancer." A California Proposition 65 warning indicates Doxorubicin hydrochloride is known to the State of California to cause cancer and birth defects or other reproductive harm. Reported solubilities include 10 mg/mL in DMSO, 0.5 mg/mL in DMSO:PBS (pH 7.2) (1:1), 1 mg/mL in ethanol, and >100 μg/mL in PBS (pH 7.2). The calculated ATEmix (oral) is 500.00 mg/kg.