DMH1, 10 mg

From STEMCELL Technologies, this dorsomorphin homolog (DMH1) is a small-molecule BMP and AMPK pathway inhibitor that selectively inhibits ALK2 and also acts on ALK3, ALK6, and AMPK. It additionally functions as a RHO/ROCK pathway inhibitor of ROCK1 and ROCK2, and is used in laboratory research to promote the differentiation of pluripotent stem cells.

The compound is a crystalline solid intended as a laboratory chemical, identified by CAS No. 1206711-16-1 and UN/ID no. UN2811, with a molecular formula of C24H20N4O and a molecular weight of 380.4. It is soluble in DMF at 20 mg/mL and in DMSO at 1 mg/mL. Under the 2012 OSHA Hazard Communication Standard, it is classified as Acute toxicity – Oral Category 3 (toxic if swallowed), with an ATEmix (oral) value of 100.00 mg/kg.