DAPT, 5 mg

A small-molecule research reagent from STEMCELL Technologies, this compound functions as a Notch pathway inhibitor by targeting γ-secretase and is listed for use in differentiation studies. It is also referred to by the synonyms GSI-IX and LY-374973, with the systematic name N-[2S-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-1,1-dimethylethyl ester-glycine and CAS No. 208255-80-5. The material is supplied as a crystalline solid and is described as chemically stable under recommended storage conditions.

According to the manufacturer's safety documentation, the product is intended for laboratory research use only and is not for human or animal diagnostic or therapeutic applications. It should be handled by trained personnel observing good laboratory practice, with adequate ventilation and personal protective equipment including safety glasses, a lab coat, and compatible chemical-resistant gloves. Store tightly closed at -20°C and keep away from strong acids and strong bases. Reported solubility values are approximately 0.1 mg/mL in 1:9 DMF:PBS (pH 7.2), ~1 mg/mL in EtOH, and ~25 mg/mL in DMF and DMSO. The substance is not considered hazardous under the 2012 OSHA Hazard Communication Standard and is not WHMIS controlled.