Compound E, 1 mg

A research-grade biochemical supplied by STEMCELL Technologies, identified as Compound E and synonymously labelled γ-Secretase Inhibitor XXI (CAS 209986-17-4). According to the manufacturer's Safety Data Sheet, the substance is a crystalline solid with a molecular weight of 490.5 and a molecular formula of C27H24F2N4O3. The product is described by the manufacturer as a Notch pathway inhibitor that inhibits γ-secretase, and is reported to accelerate the differentiation of human ES cells into primitive neural stem cells, supporting defined, serum-free neural induction workflows for human ES and iPS cells.

The Safety Data Sheet classifies the chemical as not hazardous according to the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) and the Globally Harmonized System (GHS). It is recommended for laboratory chemical use; the product is for research use only and not intended for human or animal diagnostic or therapeutic uses unless otherwise stated. The supplier is STEMCELL Technologies Canada Inc. (Suite 500 - 1618 Station Street, Vancouver, British Columbia V6A 1B6, Canada), with an emergency telephone number of 1-800-667-0322. The chemical is stated to be stable under normal conditions and incompatible with strong oxidizing agents, with storage guidance to keep containers tightly closed in a dry, cool, and well-ventilated place.