CH223191, 50 mg

A small molecule research compound supplied by STEMCELL Technologies, this crystalline solid acts as a potent and specific antagonist of the aryl hydrocarbon receptor (AhR). It blocks activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; IC50 = 0.03 µM) and prevents the induction of cytochrome P450 1A1 by TCDD in HepG2 cells and in the livers of mice. Published work describes its use in inducing expansion of human CD34+ hematopoietic stem and progenitor cells in culture.

The chemical name is 1-methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide, with chemical formula C19H19N5O, molecular weight 333.4 g/mol, CAS Number 301326-22-7, and a stated purity of ≥ 95%. Reported solubility is DMF: 30 mg/mL, DMSO: 25 mg/mL, and Ethanol: 0.1 mg/mL, with low solubility in aqueous media. The product is stable at -20°C as supplied, should be protected from prolonged exposure to light, and remains stable for 12 months from the date of receipt when stored as supplied. It is classified as harmful if swallowed and is intended for research use only.