Celastrol, 10 mg

STEMCELL Technologies supplies this small molecule as a topoisomerase II inhibitor (IC50 = 7.41 μM). The crystalline solid has a chemical formula of C29H38O4, a molecular weight of 450.6 g/mol, and a reported purity of ≥ 98%. Its full chemical name is 3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid.

The compound has been described as having neuroprotective and anti-inflammatory properties, and reported to improve memory, learning and psychomotor activity when administered in rats, with potential therapeutic relevance for neurodegenerative disorders such as Alzheimer's disease. It has also been reported to suppress TNF-α-induced NF-κB activation and to increase TNF-induced apoptosis in chronic myelogenous leukemia cells.

The product is reported as stable at -20 °C for 12 months from the date of receipt when protected from prolonged exposure to light. Reported solubility values include DMSO ≤ 95 mM and absolute ethanol ≤ 65 mM. For use as a cell culture supplement, the stock solution should be diluted into culture medium immediately before use, with the final DMSO concentration kept below 0.1% due to potential cell toxicity. The product is intended for research use only and is classified as hazardous.