Brefeldin A, 10 mg

STEMCELL Technologies supplies a portfolio of small molecules developed to support stem cell research, where these compounds serve to understand and regulate reprogramming, self-renewal, and differentiation. The product is supplied as a laboratory chemical for research use only. The compound is classified as a protein trafficking inhibitor that inhibits Sec7-containing GEF, with applications in antibiotic research and cell line development.

According to the manufacturer's overview, such small molecules are cell permeable and capable of affecting signaling pathways within the cell, more stable and cost effective than growth factors, and chemically defined for high purity and low lot-to-lot variability in activity, with effects that can be finely tuned by varying concentration. Synonyms listed on the safety documentation include Ascotoxin, BFA, Cyanein, Decumbin, and Nectrolide. The molecular formula is C16H24O4 with a molecular weight of 280.4, and it is identified by CAS number 20350-15-6.

The compound presents as a crystalline solid. Reported solubility values are ~0.5 mg/mL in 1:1 DMF:PBS (pH 7.2), ~1 mg/mL in EtOH, ~0.5 mg/mL in DMSO, and ~3 mg/mL in DMF. It is described as chemically stable and incompatible with strong oxidizing agents. It is acutely toxic if swallowed (H301) and is labelled with the signal word Danger.