BMN 673, 10 mg

A poly ADP ribose polymerase (PARP) inhibitor, BMN 673 (also known as Talazoparib), is offered by STEMCELL Technologies as a research-grade small molecule. The compound has been reported to inhibit PARP1 with an IC50 of 0.57 nM and to act on cancer cells harbouring BRCA1, BRCA2, or PTEN mutations. BMN 673 binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks, leading to DNA damage.

The molecule carries the chemical formula C19H14F2N6O and a molecular weight of 380.4 g/mol, with a reported purity of ≥ 98%. It is supplied as a crystalline solid. The product is stable at -20 °C as supplied and remains stable for 12 months from the date of receipt. STEMCELL Technologies recommends storing small molecules away from direct light and, for long-term storage, with a desiccant. Solubility information indicates ≤ 50 mM in DMSO and ≤ 655 µM in absolute ethanol, and the compound has low solubility in aqueous media.

Published research applications include trapping PARP1 at the DNA damage site and inducing cytotoxic effects in breast cancer cells, increasing CD8+ T cells and NK cells as well as IFN-γ and TNF-α production to inhibit growth of a BRCA1-deficient murine epithelial ovarian cancer cell line (BR5FVB1-Akt), and inhibiting BRCA2-associated pancreatic ductal adenocarcinoma (PDAC) growth in a PDAC murine xenograft model.