BIRB-796, 10 mg

Provided by STEMCELL Technologies, this 10 mg format of BIRB-796 (doramapimod) is a potent, cell-permeable, reversible inhibitor of p38α/β mitogen-activated protein kinase that blocks ATP binding at the kinase DFG-out conformation. Researchers apply it to suppress cytokine production, including IL-1β and TNF-α, in cell culture and primary cell models investigating signal transduction, endothelial activation, and leukocyte recruitment. The compound serves as a reference inhibitor in stress-activated kinase pathway studies, with activity in the low nanomolar range in enzymatic assays and low micromolar concentrations in cellular assays. Store at -20°C, protect from light, and reconstitute in DMSO for working stocks before further dilution in aqueous buffers. For research use only.