AZD8055, 10 mg

A potent and selective ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) supplied by STEMCELL Technologies. It targets the mTOR pathway, inhibits FKBP-12, and acts on both mTORC1 and mTORC2 complexes. The compound has an IC₅₀ value of 0.8 nM, with approximately 1000-fold selectivity for mTOR over all PI3K isoforms, and exhibits no activity against a panel of 260 kinases at concentrations up to 10 µM. Purity is reported as ≥ 98%.

The chemical name is 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-benzenemethanol, with molecular formula C₂₅H₃₁N₅O₄, molecular weight 465.5 g/mol, and CAS number 1009298-09-2 (internal code CCG-168). It is supplied as a crystalline solid. The product is stable at -20°C as supplied for 12 months from date of receipt and should be protected from prolonged exposure to light. Reported solubility is ≤ 2 mM in DMSO and ≤ 1 mM in absolute ethanol.

Published cancer research applications include inhibition of proliferation of A549 and H838 lung cancer cell lines in vitro and tumor growth in human tumor xenografts in mice; induction of cell death and reduced migration in tamoxifen-resistant (TamR) and estrogen deprivation-resistant (MCF7-X) breast cancer cell lines; induction of apoptosis in Hep-2 laryngeal cancer cells; synergistic apoptosis induction with ABT-737 in rhabdomyosarcoma cells via suppression of MCL1; and inhibition of proliferation and glycolysis in HeLa cervical cancer cells. For research use only; not intended for human or animal diagnostic or therapeutic uses.