Atipamezole (Hydrochloride), 10 mg

This research-grade compound from STEMCELL Technologies is a selective α2-adrenergic receptor antagonist presented as a crystalline solid. It is an imidazole derivative with a reported receptor binding affinity of Ki = 1.6 nM, a molecular weight of 248.8 g/mol, and the molecular formula C14H16N2 • HCl. The product is supplied at a purity of ≥ 98%.

The α2-adrenergic receptor is implicated in amyloid precursor protein processing, making this antagonist a candidate tool in Alzheimer's disease research. Published applications listed by STEMCELL include reversal of the sedative effects of α2-adrenergic receptor agonists in animals, improved efficacy of L-DOPA and apomorphine in animal models of Parkinson's disease, and enhanced serotonin and dopamine turnover in aged rats. The compound has also been used to reverse the sedative and analgesic effects of dexmedetomidine and to assess cognitive performance in rat models of Parkinson's disease.

According to the product information sheet, the compound is stable at -20°C as supplied, should be protected from prolonged exposure to light, and stored with a desiccant for long-term storage. It remains stable for 12 months from the date of receipt. The product is soluble in DMSO (≤ 40 mM) and absolute ethanol (≤ 40 mM), but has low solubility in aqueous media. Stock solutions should be freshly prepared and diluted into culture medium immediately before use, with final DMSO concentration kept below 0.1% to avoid potential cell toxicity. The safety data sheet classifies the chemical as harmful if swallowed, in contact with skin, or if inhaled, and the product is intended for research use only.