AKT Inhibitor VIII, 1 mg

A potent, reversible allosteric inhibitor of AKT1/AKT2/AKT3 kinases, this small molecule blocks downstream signaling through the PI3K-AKT-mTOR pathway without competing for the ATP-binding site. With an IC50 of approximately 130 nM against recombinant AKT1 and activity confirmed across all three isoforms, it is widely used in cancer biology, apoptosis, and cell proliferation studies. The 1 mg unit ships as a single-use vial supplied as a lyophilized powder suitable for reconstitution in DMSO for in vitro experiments and research use only. Store at -20 degrees C, protected from light, and aliquot immediately after reconstitution to minimize freeze-thaw cycles. STEMCELL Technologies provides this reagent as part of its portfolio of small-molecule pathway inhibitors for cell signaling research.