AK-7, 25 mg

A small molecule offered by STEMCELL Technologies, AK-7 is described as a neuroprotective agent and a selective sirtuin 2 (SIRT2) inhibitor, with an IC50 of 15.5 μM (Chen et al.). It is inactive against SIRT1 and SIRT3 (Taylor et al.). SIRT2 is a deacetylase that targets histone 4, α-tubulin, forkhead transcription factors of class O (FOXO), and other protein substrates, and SIRT2 activity has been connected to cancer, age-related disorders, and neurodegenerative diseases (de Oliveira et al.). As an inhibitor of SIRT2, the compound reduces neuronal death in Huntington's disease mouse models (Chopra et al.).

Its chemical name is 3-(1-Azepanylsulfonyl)-N-(3-bromophenyl)benzamide. CAS Number: 420831-40-9. Chemical Formula: C19H21BrN2O3S. Molecular Weight: 437.4 g/mol. Purity: ≥ 98%. The physical appearance is a white powder.

The product is stable at -20°C as supplied and remains stable for 12 months from date of receipt. STEMCELL recommends storing small molecules away from direct light and, for long-term storage, with a desiccant. Reported solubility values are DMSO ≤ 110 mM and absolute ethanol ≤ 18 mM. As a general guide, stock solutions are stored in DMSO at -20°C and aliquoted to avoid repeated freeze-thaw cycles. The compound has low solubility in aqueous media. For use as a cell culture supplement, stock solution should be diluted into culture medium immediately before use, avoiding final DMSO or absolute ethanol concentration above 0.1% due to potential cell toxicity. Published applications include protection against MPTP neurotoxicity and α-Synuclein toxicity in Parkinson's disease mouse models (Chen et al.), promotion of neuronal survival in Huntington's disease mouse models (Chopra et al.), improvement of brain ischemia outcomes in mice with enhanced P38 activation and decreased infarction volume (Wu et al.), and reduction of cochlear cell apoptosis with attenuation of noise-induced hearing loss (Liu et al.). Products are for research use only.