A 83-01, 5 mg

Offered by STEMCELL Technologies, this small molecule acts as a potent inhibitor of the Activin/NODAL/TGF-β signalling pathway by targeting activin receptor-like kinases ALK5, ALK4, and ALK7, with reported IC50 values of 12 nM, 45 nM, and 7.5 nM, respectively. Known as A 83-01, the compound has the chemical formula C25H19N5S, a molecular weight of 421.5 g/mol, and a stated purity of ≥ 95%. It is supplied as a crystalline solid with low solubility in aqueous media and is recommended for dissolution in DMSO at concentrations up to 45 mM.

In published research, the inhibitor has been applied to facilitate the conversion of epiblast stem cells to the naïve pluripotent state, to enable OCT4-mediated reprogramming in combination with PD0325901, to inhibit mesoderm and endoderm specification, and to disrupt epithelial-to-mesenchymal transition through inhibition of the SMAD signalling pathway. The product is intended for research use only and is not approved for human or animal diagnostic or therapeutic applications.