3-Deazaneplanocin A , 500 ug

Supplied by STEMCELL Technologies as a 500 ug vial of research-grade tool compound, 3-Deazaneplanocin A (DZNep) is a cyclopentenyl adenosine analog widely used to interrogate epigenetic regulation in cell culture. This small molecule selectively inhibits S-adenosylhomocysteine hydrolase (SAHH) and suppresses EZH2, the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), thereby reducing trimethylation of histone H3 at lysine 27 (H3K27me3) and reactivating silenced tumor suppressor genes. Investigators apply DZNep at working concentrations of 0.1 to 5 uM across 24 to 72 hour exposures to study chromatin remodeling, apoptosis induction, and differentiation in hematological cancer models and pluripotent stem cell systems. The lyophilized powder is stored at -20°C, protected from light, and reconstituted in sterile DMSO before dilution into aqueous media. Each vial supports multiple independent experiments in molecular biology, gene expression analysis, and stem cell differentiation protocols, and is intended for research use only.