1-Azakenpaullone, 5mg

A selective small-molecule inhibitor of glycogen synthase kinase-3β (GSK-3β), 1-Azakenpaullone from STEMCELL Technologies is supplied as a 5 mg vial of lyophilized powder suitable for in vitro cell culture workflows. The compound modulates Wnt/β-catenin signaling and is widely used to maintain pluripotency in human and mouse stem cell cultures, drive neural differentiation of embryonic stem cells, and study tau phosphorylation relevant to Alzheimer's and neurodegeneration research. As a structural analog of kenpaullone, it offers improved selectivity for GSK-3β over closely related kinases such as CDK1 and CDK5. Reconstitute in DMSO to prepare stock solutions, aliquot into single-use tubes to minimize freeze-thaw cycles, and store at -20°C protected from light to preserve compound integrity. Typical working concentrations fall in the low micromolar range for kinase inhibition assays and directed differentiation protocols. Provided by STEMCELL Technologies for research use only; not intended for diagnostic or therapeutic applications.