Trolox, 250 mg

This vitamin E analog from STEMCELL Technologies is a cell-permeable, hydrophilic small molecule used in research settings. The manufacturer lists the alternative chemical name 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, with a chemical formula of C14H18O4 and a molecular weight of 250.3 g/mol. Reported purity is ≥ 98% (CAS Number 53188-07-1).

The product is supplied as a crystalline solid. It is stable at -20°C as supplied and should be protected from prolonged exposure to light; for long-term storage, the manufacturer recommends storing with a desiccant. The product is stated to be stable as supplied for 12 months from date of receipt. Documented solubility values include PBS (pH 7.2) at ≤ 11 mM, DMSO at ≤ 75 mM, and absolute ethanol at ≤ 75 mM.

Published research applications described by the manufacturer include inducing beta-like cell differentiation from human embryonic stem cells, and enhancing arsenic-mediated apoptosis in myeloma and breast cancer cells. The compound has also been reported in studies to suppress osteoclast formation by downregulating RANKL induction and c-Fos expression in mice, and to prevent cisplatin-induced apoptosis in renal epithelial cells. Products are for research use only.