Sinomenine (HCl), 50 mg

From STEMCELL Technologies, this small molecule is a natural plant alkaloid with anti-inflammatory activity, commonly used in research to alleviate inflammation associated with rheumatoid arthritis. It impairs signaling through Nuclear factor-kappa B (NF-κB) and enhances the bioavailability of some compounds, at least in part through inhibition of drug export by transporters such as P-glycoprotein.

Supplied as the hydrochloride salt, the compound is a crystalline solid with a molecular weight of 365.9 g/mol and a purity of ≥ 98%. It is stable at -20°C as supplied and should be protected from prolonged exposure to light, remaining stable for 12 months from date of receipt. Reported solubility values are ≤ 13 mM in PBS (pH 7.2), ≤ 80 mM in DMSO, and ≤ 13 mM in absolute ethanol.

Published applications include the promotion of self-renewal in cultured human and mouse embryonic stem cells. The product is classified as hazardous; users should refer to the Safety Data Sheet.