Raloxifene (HCl), 100 mg

Supplied by STEMCELL Technologies as a hydrochloride salt, this small molecule is a selective estrogen receptor modulator (SERM). It exhibits agonistic, estrogenic activity in bone cells without stimulating estrogen receptor activity in breast or uterine tissues. The compound is also known by the alternative names Evista®, Keoxifene, and LY156758.

The chemical name is 6-Hydroxy-2-(p-hydroxyphenyl)benzo[b]thien-3-yl-p-(2-piperidinoethoxy)phenyl ketone hydrochloride, assigned CAS Number 82640-04-8, with the molecular formula C₂₈H₂₇NO₄S · HCl and a molecular weight of 510.2 g/mol. The product is a crystalline solid with a stated purity of ≥ 98%. It should be stored at -20°C and protected from prolonged exposure to light. Reported solubility is ≤ 190 µM in absolute ethanol and ≤ 19 mM in DMSO; the compound has low solubility in aqueous media. To prepare a 10 mM stock solution in DMSO, 1 mg should be resuspended in 196 µL of fresh DMSO, prepared fresh before use. Final DMSO concentration in culture medium should not exceed 0.1% due to potential cell toxicity.

Published applications include enhancement of osteoblast differentiation in mouse bone marrow and human osteoblast cultures, inhibition of osteoclast differentiation in primary human bone marrow mononuclear cell cultures, and reduction of endodermal differentiation (HNF-4α expression) in embryoid bodies derived from human embryonic stem cells.