QIAseq Multimodal Panel (12)

QIAGEN offers a consolidated library preparation solution for targeted next-generation sequencing that enables simultaneous DNA and RNA enrichment and analysis from a single sample. Unlike approaches that require 2 separate workflows for DNA and RNA, the panels start with total nucleic acids (DNA + RNA) and prepare UDI-containing, Illumina-compatible targeted DNA and RNA libraries using a single-day, consolidated workflow, conserving samples of limited availability.

The library insert size is approximately 150 bp, making the workflow highly compatible with low-quality samples such as FFPE specimens. The panels have been designed for use with low-yield and poor-quality biological samples. From this single workflow, DNA biomarkers including single nucleotide variants (SNVs), insertions and deletions (InDels), and copy number variants (CNVs) can be detected, alongside RNA biomarkers including fusions, exon skipping events, and gene expression levels. Total nucleic acids can be isolated using dedicated sample isolation protocols developed specifically for the panels. The ability to simultaneously detect DNA and RNA biomarkers has been benchmarked against two separate workflows, namely QIAseq Targeted DNA Panels and QIAseq RNA Fusion XP Panels.

Popular product options within the portfolio include the QIAseq Multimodal Human Pan Cancer Panel (GeneGlobe ID: UHS-5000Z), Human Sarcoma Panel (UHS-006Z), Human Lung Cancer Panel (UHS-005Z), and Human Leukemia Panel (UHS-009Z).