QIAseq Multimodal Custom Panel HT (96)

This high-throughput custom sequencing panel from QIAGEN enables simultaneous analysis of DNA variants and RNA biomarkers from a single sample input, supporting unified detection of single-nucleotide variants, small insertions and deletions, copy number variations, gene fusions, and gene expression levels in one workflow. The 96-sample format eliminates the need for separate DNA-seq and RNA-seq library preparations, making it a practical choice for translational genomics laboratories.

Built on QIAseq molecular barcoding chemistry, the panel incorporates Unique Molecular Indexes to correct PCR amplification bias and improve quantification accuracy, supporting reliable detection of low-allele-frequency variants down to 0.1% in cfDNA and tumor samples. Each panel is designed to customer-specified genomic regions, typically ranging from 10 kb to 1 Mb of target content, and is compatible with Illumina sequencing platforms.

The HT configuration supports automated processing of 96 samples per run, with input requirements as low as 10 ng of total nucleic acid or 1 ng of cfDNA. The single-day workflow combines DNA enrichment, RNA capture, and library preparation with streamlined bead-based cleanup, well-suited for oncology research, biomarker discovery, and liquid biopsy studies. The accompanying QIAseq secondary analysis pipeline provides variant calling, fusion detection, and expression quantification in an integrated workflow.

Designed for research use only; not intended for diagnostic procedures.