QIAseq Multimodal Custom Panel (96)

A single-day sample-to-sequencing workflow is provided by QIAGEN through QIAseq Multimodal Custom Panels, enabling simultaneous enrichment and profiling of DNA variants alongside RNA targets from a single sample input. Unlike approaches that require separate workflows for DNA and RNA analysis, these panels start with total nucleic acids (or DNA plus RNA) and prepare UDI-containing, Illumina-compatible targeted libraries in one consolidated process, conserving samples of limited availability and reducing hands-on time.

The panels are designed for use with low-yield and poor-quality biological samples, including FFPE material, with a library insert size of approximately 150 bp. Custom designs can be configured to target exonic regions of genes, hotspots or SNPs, intronic and promoter regions, known gene fusions based on characterized breakpoints, or to discover novel fusions. The ability to simultaneously detect DNA and RNA biomarkers has been benchmarked against two separate workflows, namely QIAseq Targeted DNA Pro and QIAseq Targeted Fusion XP. Dedicated sample isolation protocols have been developed specifically for these panels to support the consolidated workflow from total nucleic acids.