Phorbol 12-myristate 13-acetate, 1 mg

A potent phorbol ester widely used in cell biology and immunology research, Phorbol 12-myristate 13-acetate (PMA) from STEMCELL Technologies is supplied as a 1 mg vial of lyophilized powder for reconstitution. As a direct protein kinase C (PKC) activator, it mimics diacylglycerol to trigger downstream signaling cascades involved in cell proliferation, differentiation, and apoptosis.

Researchers commonly pair PMA with calcium ionophores such as ionomycin to drive polyclonal T cell and B cell activation in vitro, and it is frequently applied to model neutrophil oxidative burst, monocyte cytokine release, and megakaryocyte maturation in cell culture workflows. The compound is also used to induce differentiation of myeloid leukemia cell lines and to stimulate cytokine production in primary human peripheral blood mononuclear cells.

Store the dry powder at -20 degrees C protected from light and avoid repeated freeze-thaw cycles to preserve activity; reconstituted stocks are typically diluted into DMSO or ethanol and kept frozen in single-use aliquots. For research use only.