Ms Recom LIF, 10 µg

A recombinant protein for research applications is offered by STEMCELL Technologies under the Mouse Recombinant LIF designation. The product is intended as a laboratory reagent, with the supplier's quality management system certified to ISO 13485. It is labeled for research use only and is not intended for human or animal diagnostic or therapeutic applications unless otherwise stated.

The material is supplied as a powder and is not classified as a hazardous substance or mixture under the Globally Harmonized System (GHS). It is described as stable under normal conditions, with recommended storage in tightly closed containers kept in a dry, cool, and well-ventilated place.

According to the manufacturer's product information, LIF (leukemia inhibitory factor) plays a role in implantation by regulating proliferation, invasion, and differentiation of trophoblast following blastocyst attachment. Biological activity has been tested by the ability of the recombinant protein to promote proliferation of M1 cells, measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum, and the EC50 in the cited example is 2.7 pg/ml. The protein has a predicted molecular mass of 19.9 kDa, demonstrated by SDS-PAGE analysis with Coomassie Blue staining under reducing and non-reducing conditions.