Hu Abeta1-42 peptide (TFA salt), 0.5 mg

Offered by STEMCELL Technologies as a research-use reagent, this synthetic peptide is supplied as a lyophilized trifluoroacetate salt formulation with the sequence DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA. It corresponds to the Human Amyloid-β (1-42) peptide, also referred to as Aβ (1-42) or Aβ42, with a predicted molecular mass of 4514.0 g/mol and a stated purity of ≥ 95%. According to the safety data sheet, the material is soluble in DMSO.

The peptide is described as a neurotoxic fragment that can oligomerize into amyloid plaques linked to the onset of Alzheimer's disease and that modulates Bcl-2 and Bax expression in human neurons. Published applications include inducing neuronal death in human neurons both in vitro and in vivo and increasing TNF-α production in rat astrocytes. The manufacturer notes that oligomers and fibrils derived from this peptide are considered neurotoxic and recommends consulting a workplace safety committee before working with the material.

The product is recommended for storage at -20°C and is stated to be stable as supplied until the expiry date on the label. The safety data sheet classifies the material as not a hazardous substance or mixture according to the Globally Harmonized System (GHS) and indicates it is not regulated for transport under DOT, TDG, IATA, or IMDG.