IQ-1, 5 mg

Small-molecule Wnt pathway research tools from STEMCELL Technologies include this 5 mg unit of IQ-1, a cell-permeable CBP/beta-catenin antagonist widely used to probe canonical Wnt signaling in stem cell biology. The compound disrupts the CBP-beta-catenin protein-protein interaction, suppressing beta-catenin-driven transcription and supporting maintenance of naive pluripotency in mouse embryonic stem cell cultures when combined with MEK inhibition.

Investigators deploy IQ-1 in cell culture workflows to limit spontaneous differentiation, examine Wnt contributions to lineage specification, or assemble 2i/3i-style inhibitor cocktails alongside MEK and GSK3 modulators such as PD0325901 and CHIR99021. Each vial is intended for in vitro research use only; the powder should be stored at -20 degrees C, protected from light, with stock solutions prepared in DMSO and aliquoted to minimize repeated freeze-thaw cycles.

The inhibitor is typically applied at micromolar working concentrations that researchers titrate to their specific stem cell maintenance, differentiation, or reporter-based signaling assays.