Hu Recom Oncostatin M, ACF, 10 µg

STEMCELL Technologies Human Recombinant Oncostatin M is an animal component-free recombinant cytokine for cell biology research. Oncostatin M (OSM) is a member of the interleukin 6 (IL-6) family of cytokines and bears close resemblance in amino acid sequence to leukemia inhibitory factor (LIF) and granulocyte colony-stimulating factor (G-CSF). OSM signals through the type I receptor, consisting of gp130 and LIF receptor (LIFR), and the type II receptor, consisting of gp130 and OSM receptor (OSMR), which activate the JAK/STAT pathway. The protein is primarily produced by activated T cells and monocytes, and also by activated macrophages, neutrophils, mast cells, and dendritic cells. Within the bone microenvironment, it is produced by cells of both hematopoietic and mesenchymal origin, including osteocytes and osteoblasts.

Oncostatin M has roles in differentiation, cell proliferation, hematopoiesis, inflammation, liver development, and bone formation and resorption. The biological activity of the recombinant protein was tested by its ability to promote the proliferation of TF-1 cells, with an EC50 of 0.21 ng/mL. SDS-PAGE analysis with Coomassie Blue staining indicates a predicted molecular mass of 22.3 kDa. This product is animal component-free.