Hu Recom IL-7, 100 µg

STEMCELL Technologies offers this Human Recombinant IL-7 as a lyophilized protein produced in E. coli. Interleukin 7 is a member of the type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus and lymphoid organs, and by bone marrow stromal cells. IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Rα (CD127) and signals through the JAK/STAT and PI3K pathways. The cytokine regulates the survival of naive and memory CD4+ and CD8+ T cells, γ/δ T cells, NKT cells, innate lymphoid cells, and regulatory T cells. Stimulation of human B cell precursors with IL-7 can promote STAT5-dependent proliferation and survival in vitro.

The product is supplied as a lyophilized powder from a sterile-filtered aqueous solution containing sodium phosphate at pH 7.5. The specific activity is ≥ 2 x 10^6 units/mg, as determined by a cell proliferation assay using phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMCs), with an EC50 ≤ 0.5 ng/mL. The endotoxin level is ≤ 1 EU/μg protein and the purity is ≥ 97%. The product is for research use only and is not intended for human or animal diagnostic or therapeutic uses unless otherwise stated.