Hu Recom IL-21, ACF, 10 µg

STEMCELL Technologies supplies this animal component-free recombinant human Interleukin-21 (IL-21) as a 10 µg vial of lyophilized protein for immunology and cell culture research. IL-21 is a type I cytokine of the common gamma-chain receptor family that signals primarily through JAK1/JAK3 and STAT3, driving proliferation and differentiation of activated T cells, B cells, and natural killer cells. Researchers use this preparation in vitro to study T follicular helper cell differentiation, plasma cell generation, NK cell maturation assays, and expansion protocols for chimeric antigen receptor (CAR) T cells.

The ACF (animal component-free) designation indicates the protein is produced without animal-derived raw materials, an attribute valued in defined culture systems and translational cell therapy workflows where xeno-free traceability matters. Reconstitute each vial with sterile, endotoxin-free water to a working stock, then aliquot and freeze at -80 °C; the lyophilized powder should be stored refrigerated and protected from light. Avoid repeated freeze-thaw cycles to preserve full bioactivity, and titrate dosing empirically when optimizing lymphocyte stimulation assays, as effective concentrations typically fall in the low ng/mL range depending on cell type and readout.

Intended for research use only, this recombinant human IL-21 supports reproducible studies of cytokine signaling, antibody class switching, and immune regulation in primary human lymphocyte culture, complementing other cytokines such as IL-2, IL-7, and IL-15 in mixed treatment regimens.