Hu Recom IL-1 beta, 1000 µg

Manufactured by STEMCELL Technologies, Human Recombinant IL-1 beta is a research-use-only laboratory reagent supplied as a solid powder. According to the manufacturer's Safety Data Sheet, the product is not classified as a hazardous substance or mixture under the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) or the Globally Harmonized System (GHS).

IL-1β is a cytokine that promotes extravasation of immunocompetent cells into affected tissues and stimulates Th17 differentiation and B cell proliferation. The biological activity of the recombinant protein was tested by its ability to promote the proliferation of D10S cells, with cell proliferation measured after 66 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum, and the EC50 in the cited example is 0.7 - 1 pg/mL. The protein has a predicted molecular mass of 17.5 kDa and was resolved by SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Per the Safety Data Sheet, the product is stable under normal conditions, and no special protective equipment is required for eye/face, skin/body, or respiratory protection under normal use. Containers should be kept tightly closed in a dry, cool and well-ventilated place. The product is intended for research use only and is not intended for human or animal diagnostic or therapeutic uses unless otherwise stated.