Hu Recom IGFBP-4, 50 µg

Recombinant human Insulin-like Growth Factor Binding Protein 4 (IGFBP-4) supplied as a 50 µg aliquot from STEMCELL Technologies supports mechanistic studies of IGF-1 and IGF-2 sequestration in cell-based assays. The protein binds circulating insulin-like growth factors with high affinity, modulating downstream signaling through the IGF-1 receptor and influencing cell proliferation, survival, and lineage commitment in vitro.

Researchers apply this reagent to interrogate stem cell self-renewal and differentiation, including hematopoietic and mesenchymal culture systems, as well as osteoblast and chondrocyte maturation models. The recombinant factor is also deployed in tumor biology workflows where IGFBP-4 acts as a context-dependent tumor suppressor, in reproductive endocrinology investigations of folliculogenesis and placental development, and in metabolic studies of growth hormone axis regulation. Supplied as a lyophilized powder in a single-use vial, the protein is reconstituted in buffered aqueous solution for direct addition to serum-free or defined culture media.

For handling, maintain the lyophilized material at -20 °C with desiccation; aliquot working solutions to avoid repeated freeze-thaw cycles. Bioactivity is verified through functional binding assays, and purity is confirmed by SDS-PAGE. This research-use-only reagent is intended for laboratory investigation of IGF pathway modulation and is not approved for diagnostic or therapeutic applications.