Doxorubicin (Hydrochloride), 5 mg

From STEMCELL Technologies, this laboratory chemical is an anthracycline antibiotic that intercalates DNA and inhibits DNA topoisomerase II, with the synonym DOX. It is supplied as a crystalline solid and is identified by CAS No. 25316-40-9, with a molecular formula of C27H29NO11 • HCl and a molecular weight of 580.0.

Solubility data indicate compatibility with several common solvents: DMSO at 10 mg/mL, a 1:1 mixture of DMSO and PBS (pH 7.2) at 0.5 mg/mL, ethanol at 1 mg/mL, and PBS (pH 7.2) at >100 μg/mL. The product is classified as a laboratory chemical and is stable under recommended transport or storage conditions, though it should be kept away from strong oxidizing agents.

Under the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200), the chemical is classified for Acute toxicity – Oral (Category 4) and Carcinogenicity (Category 1B), with the hazard statements "Harmful if swallowed" and "May cause cancer." A California Proposition 65 warning notes that Doxorubicin hydrochloride is known to the State of California to cause cancer and birth defects or other reproductive harm. Handling precautions call for obtaining special instructions before use, wearing protective gloves, clothing, eye and face protection, and washing exposed skin thoroughly after handling. The supplier is STEMCELL Technologies Canada Inc., Suite 500 - 1618 Station Street, Vancouver, British Columbia V6A 1B6 Canada, with an emergency telephone at 1-800-667-0322.