Dibutyryl-cAMP (Na Salt), 250 mg

A cell-permeable cyclic AMP (cAMP) analog supplied as the sodium salt by STEMCELL Technologies. This small molecule activates cAMP-dependent protein kinases and is described as a cAMP pathway activator for research use.

The compound has the chemical name N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate) 2'-butanoate-adenosine, monosodium salt, with CAS number 16980-89-5, molecular formula C₁₈H₂₃N₅O₈P · Na, and a molecular weight of 491.4 g/mol. Reported purity is ≥ 95%. The product is provided as a crystalline solid and is stable at -20°C for 12 months from date of receipt when protected from prolonged light exposure; long-term storage with a desiccant is recommended.

Stock solutions can be prepared in water (≤ 100 mM) or DMSO (≤ 100 mM); for example, resuspending 10 mg in 2.04 mL of water yields a 10 mM stock. Published applications include suppressing experimental autoimmune encephalomyelitis development by reducing demyelination and mobilizing neural stem cells, inducing intrinsic axon growth in peripheral and central nervous systems along with morphological differentiation of astrocytes, and stimulating neurite outgrowth in PC12 cells.