Dibutyryl-cAMP (Na Salt), 100 mg

A cell-permeable cyclic AMP analog supplied as the sodium salt, this small-molecule research reagent from STEMCELL Technologies activates cAMP-dependent protein kinases. It is provided as a crystalline solid with the alternative names Bucladesine and DC 2797, CAS Number 16980-89-5, a molecular weight of 491.4 g/mol, and a chemical formula of C₁₈H₂₃N₅O₈P · Na. The product is supplied at a purity of ≥ 95%.

Published applications cited in the product literature include suppression of experimental autoimmune encephalomyelitis development by reducing demyelination and mobilizing neural stem cells in the subventricular zone toward demyelinated plaques, induction of intrinsic axon growth in peripheral and central nervous systems along with morphological differentiation of astrocytes, and stimulation of neurite outgrowth in PC12 cells.

According to the manufacturer's safety documentation, the compound is not classified as hazardous under the Globally Harmonized System. Reported solubility values are ~3.3 mg/mL in PBS (pH 7.2), ~1 mg/mL in EtOH, and ~5 mg/mL in DMF. Reported acute toxicity values include an oral LD50 of > 5 g/kg (rat) and a dermal LD50 of > 2 g/kg (rat). The product is for research use only and is not intended for human or animal diagnostic or therapeutic uses unless otherwise stated.