CP-945,598 (Hydrochloride), 10 mg

A selective cannabinoid type 1 (CB1) receptor antagonist supplied by STEMCELL Technologies. CP-945,598 exhibits a Ki of 0.7 nM at CB1 receptors and shows low affinity for CB2 receptors (Ki = 7.6 μM). CB1 receptors belong to the G protein-coupled receptor (GPCR) superfamily, are abundant in the brain, and can attenuate neurotransmission. Endocannabinoid system components are expressed in the basal ganglia and interact with GABAergic and dopaminergic signaling pathways, and modulation of CB1 has been discussed as a potential therapeutic target in Parkinson's disease.

The compound is provided as a crystalline solid with a reported purity of ≥ 98%. Its alternative name is Otenabant (CAS Number 686347-12-6; chemical formula C25H25Cl2N7O • HCl; molecular weight 546.9 g/mol). It is soluble in DMSO at concentrations up to 540 μM but has low solubility in aqueous media. For storage, the product is stable at -20 °C and should be protected from prolonged exposure to light; long-term storage is recommended with a desiccant. Stock solutions in DMSO are recommended for storage at -20 °C, aliquoted to limit repeated freeze-thaw cycles.

Among published applications, the compound has been reported to alter fat oxidation and energy expenditure in rats. The product is intended for research use only and not for human or animal diagnostic or therapeutic uses unless otherwise stated.