Anti-ZPR1 Antibody

The ZPR1 zinc finger protein is a key component of the survival motor neuron (SMN) complex, where it binds SMN and facilitates the assembly of small nuclear ribonucleoproteins (snRNPs). Disruption of this interaction has been linked to spinal muscular atrophy (SMA) pathogenesis, making ZPR1 a valuable target for motor neuron and neurodegenerative disease research.

This rabbit polyclonal antibody from Antibodies.com is raised against human ZPR1 and shows reactivity with mouse samples, supporting translational studies across common laboratory models. The unconjugated IgG formulation provides flexibility for downstream detection, including HRP- or fluorophore-based secondary labeling in western blot workflows.

Each vial contains 100 µl of antibody, supplied in a format intended for research use only in vitro applications. Recommended storage at -20°C preserves reagent activity for repeated experiments, while aliquoting upon first use helps minimize freeze-thaw cycles that could compromise binding performance.

Validation in western blot enables detection of endogenous ZPR1 expression in cell lysates and tissue homogenates, supporting studies into snRNP biogenesis, RNA splicing, and SMA-related signaling pathways.