Anti-ZNF398 Antibody

This unconjugated polyclonal antibody from Antibodies.com targets ZNF398, a zinc finger protein that functions as a transcription factor in human cells. Raised in rabbit hosts and supplied as a 100 µl liquid aliquot, the reagent is validated for Western blot (WB) and immunofluorescence (IF) workflows, supporting detection of endogenous ZNF398 in cultured human cell lines and tissue specimens.

ZNF398 belongs to the KRAB-containing subfamily of C2H2 zinc finger proteins, members of which recruit transcriptional co-repressors through their KRAB domain and bind DNA via tandem zinc finger motifs. Immunodetection of ZNF398 is used in studies of transcriptional regulation, chromatin-associated gene silencing, and differentiation-associated expression programs in human model systems.

With reactivity restricted to human samples and an unconjugated format, the antibody gives researchers flexibility to pair it with their preferred secondary labels or fluorophores. The polyclonal nature of the reagent enables recognition of multiple epitopes on ZNF398, which can strengthen signal in Western blot applications where epitope masking by sample preparation is a concern.

For immunofluorescence, optimization of fixation and permeabilization conditions is recommended; for Western blot, standard RIPA lysates prepared from human cell lines provide a reliable starting material. Store refrigerated and protect from light to preserve activity across multiple experiments.