Anti-ZNF259 Antibody

This unconjugated polyclonal antibody from Antibodies.com targets ZNF259, a zinc finger protein (also called ZPR1) that participates in EGF receptor signal transduction, binds the SMN complex, and supports cell proliferation and transcriptional regulation in mammalian systems. Raised in rabbit, the reagent is supplied as 100 µl of ready-to-use polyclonal antiserum and is validated for western blot, immunohistochemistry, and immunofluorescence workflows on human samples.

ZNF259/ZPR1 is best known for its dual localization to the cytoplasm and nucleus, where it bridges growth-factor signaling to RNA processing machinery. Researchers use this antibody to investigate SMN-dependent assembly of small nuclear ribonucleoproteins, EGF-stimulated mitogenic responses, and altered expression patterns reported in spinal muscular atrophy and certain solid tumors. The unconjugated format allows laboratories to pair the primary reagent with HRP, fluorophore, or biotin secondaries of their choice, supporting flexible detection strategies across fixed-section imaging and lysate-based blotting.