Anti-ZNF238 Antibody

Raised in rabbit against the zinc-finger transcriptional repressor ZNF238 (also known as ZBTB18 and RP58), this polyclonal IgG reagent from Antibodies.com is supplied as an unconjugated 200 µl aliquot for western blot work on mouse samples. ZNF238/ZBTB18 acts through KRAB-zinc finger and BTB/POZ domains to recruit co-repressors and histone deacetylases, and it has documented roles in cortical neurogenesis, cerebellar granule cell differentiation, and proliferation control in neural progenitors. Research applications include tracking RP58 expression across developmental brain stages, profiling its induction in differentiating neural stem cells, and comparing levels in murine glioma or medulloblastoma models where deregulated repression has been reported. The antibody recognizes endogenous ZNF238 under denaturing SDS-PAGE conditions, and the unconjugated format allows pairing with HRP- or fluorophore-labeled secondary reagents to match individual blot detection setups. Storage in working aliquots at -20 °C preserves activity across multiple experiments.