Anti-ZNF169 Antibody

Raised in rabbit and affinity-purified as an unconjugated IgG polyclonal, this reagent from Antibodies.com targets ZNF169, a 603-amino-acid KRAB-domain transcription factor containing thirteen C2H2-type zinc fingers. The antibody is supplied as 200 µl of liquid in a vial and is validated for western blot and immunohistochemistry on human, mouse, and rat samples. ZNF169 maps to chromosome 9q22, a region linked to colon cancer, basal cell carcinoma, and Gorlin syndrome, and is most strongly expressed in kidney, with weaker signals in spleen, liver, small intestine, and heart. As a member of the KRAB-ZNF family, ZNF169 is thought to engage the TRIM28/KAP1 co-repressor axis, recruiting SETDB1-mediated H3K9 trimethylation to silence endogenous retroelements and to participate in the autoregulatory loop that keeps KRAB-ZNF gene clusters repressed in many cell types. The reagent's polyclonal format broadens epitope coverage across the multi-zinc-finger protein, which is useful when individual finger motifs are variably accessible in fixed or denatured preparations. Predicted molecular weight of the human target is around 68 kDa, with synonyms recorded as MGC51961. For best long-term performance, store the vial at -20 °C in working aliquots to avoid repeated freeze-thaw cycles, with a short-term working stock kept refrigerated. Researchers studying transcriptional regulation, chromatin remodeling, and disease contexts including bladder carcinoma and autoimmunity have used anti-ZNF169 antibodies to probe expression patterns in normal and pathological tissue. The unconjugated format makes the reagent suitable for downstream fluorescent, HRP, or biotin labeling depending on the chosen secondary detection chemistry.