Anti-ZNF169 Antibody

Raised in rabbit as an unconjugated polyclonal IgG, this Antibodies.com reagent targets zinc finger protein 169 (ZNF169), a KRAB-domain-bearing C2H2-type transcription factor encoded at chromosomal locus 9q22.32 and built around 13 Kruppel-type zinc finger domains. The 100 µl vial is validated for western blot detection of endogenous protein and for immunohistochemistry on formalin-fixed tissue sections, with confirmed reactivity against human, mouse, and rat samples. The target has been reported to be highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine, and absent from adult brain and spinal cord, aligning with its documented role in autophagy regulation and in several solid tumor contexts. Recent literature has used related antibodies to probe ZNF169's contribution to colorectal cancer proliferation through transcriptional upregulation of ANKZF1 in HCT-116, HT-29, and RKO cell lines, and its involvement in thyroid cancer progression. For handling, aliquot upon first thaw, store refrigerated, protect from light, and limit freeze-thaw cycles to preserve activity through the stated shelf life.