Anti-ZMPSTE24 Antibody

The ZMPSTE24 zinc metalloprotease catalyzes the final proteolytic cleavage of prelamin A, converting it into mature lamin A, a step required for proper nuclear lamina assembly. Loss-of-function mutations in this CAAX prenyl protease underlie premature aging disorders including Hutchinson-Gilford progeria, mandibuloacral dysplasia, and restrictive dermopathy.

This polyclonal antibody from Antibodies.com is raised in rabbit and supplied as 100 µl of IgG in unconjugated format, validated for western blot and immunohistochemistry on both human and mouse samples. The reagent detects endogenous ZMPSTE24 in cell and tissue lysates, supporting studies of lamin A maturation, nuclear envelope integrity, and progeroid disease models. For handling, aliquot the antibody and store frozen, limiting repeated freeze-thaw cycles to preserve binding activity.