Anti-ZIC1 / 2 / 3 Antibody

This rabbit polyclonal reagent from Antibodies.com is raised against the ZIC1, ZIC2, and ZIC3 zinc-finger transcription factors, a small family of C2H2-type zinc finger proteins best known for their contributions to early neural tube patterning, cerebellar granule-cell development, and left-right axis specification. Because the three paralogs share a highly conserved zinc-finger domain, a polyclonal antiserum is a practical way to capture the whole family in a single blot or tissue section rather than running three separate primaries.

The antibody is supplied as 100 µl of unconjugated antiserum in a vial and is validated for Western blot (WB) and immunohistochemistry (IHC) on human and mouse samples, covering the two most common ways this family is interrogated - expression profiling in tumor panels and developmental tissue work. Researchers studying medulloblastoma subgroups, Dandy-Walker malformation, holoprosencephaly, or heterotaxy-associated cohorts frequently rely on ZIC1/2/3 staining to stratify samples or confirm animal model systems.

For handling, store the vial refrigerated at -20 °C in working aliquots to limit freeze-thaw cycles, and avoid leaving it at room temperature for extended periods. The unconjugated format leaves users free to pair it with HRP, biotin, or fluorophore-conjugated secondaries, depending on whether the downstream read-out is chromogenic IHC or chemiluminescent Western blot detection.