Anti-ZEB1 Antibody

This rabbit polyclonal reagent from Antibodies.com targets ZEB1, a zinc-finger E-box-binding transcription factor that drives epithelial-mesenchymal transition and is implicated in tumour invasion, fibrosis, and developmental patterning. Supplied as 100 µl of unconjugated antisera, the antibody is validated for western blot, immunohistochemistry, and immunofluorescence workflows against human, mouse, and rat samples.

Researchers commonly deploy it to track EMT-associated shifts in carcinoma cell lines, to map ZEB1 expression across tissue sections from breast, colorectal, and pancreatic tumours, and to probe its interplay with TGF-β, Snail, and Slug signalling networks. The polyclonal format recognises multiple epitopes on the ZEB1 protein, which is helpful when investigating post-translational modifications or splice variants that may escape monoclonal detection.

Compatible with nuclear and cytoplasmic staining patterns depending on the fixation protocol, this reagent supports studies linking ZEB1 upregulation to metastasis, chemoresistance, and poor prognosis in solid malignancies.