Anti-ZC3H11A Antibody

This polyclonal antibody from Antibodies.com recognizes ZC3H11A, a CCCH-type zinc finger protein that functions in nuclear mRNA export and has been identified as a host cofactor required for HIV-1 replication. The reagent is raised in rabbit (IgG isotype), supplied unconjugated in a 200 µL volume, and validated for Western Blot detection of the human target.

ZC3H11A localizes to nuclear speckles and participates in the export of poly(A)+ mRNA through the nuclear pore complex. RNAi screens in mammalian cells originally identified ZC3H11A as a factor whose knockdown suppresses HIV-1 gene expression at a post-transcriptional step, positioning the protein at the intersection of cellular RNA metabolism and viral replication.

Suitable for Western Blot on human cell and tissue lysates, the polyclonal format provides recognition of multiple epitopes on the target protein, supporting reproducible detection across varying expression conditions. Aliquot upon receipt to preserve activity across multiple experiments. For research use only.